Our potent and partially selective hD₃ dopamine receptor fluorescent ligand shows high affinity for hD₃ receptor and partial selectivity over the other receptor subtypes (K_i = 65.6 nM for hD₃ receptor in radioligand binding assay). It has been validated in Fluorescence Polarization binding assays as a valid alternative to radioligand binding assays. It allows to perform cell visualization in fluorescence microscopy, confocal microscopy and high content system experiments. It is potentially suitable for other fluorescence-based assays.

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https://www.frontiersin.org/articles/10.3389/fmolb.2023.1119157/full