Identifying new E3 Ubiquitin ligase ligands for new PROTACs design is a key element that can improve selective proteasomal-dependent degradation of proteins of interest involved in many pathological processes such as cancer, chronic anaemia, and ischemia.

Our fluorescent probe for VHL E3 ligase is a powerful tool both for compound screening for new E3ligase ligands and for PROTACs analysis

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